Haematopoietic development and immunological function in the absence of cathepsin D

Abstract

Cathepsin D is a well-characterized aspartic protease expressed ubiquitously in lysosomes. Cathepsin D deficiency is associated with a spectrum of pathologies leading ultimately to death. Cathepsin D is expressed at high levels in many cells of the immune system, but its role in immune function is not well understood. This study examines the reconstitution… (More)
DOI: 10.1186/1471-2172-8-22

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