Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

@article{Fukui2001HaematopoieticCC,
  title={Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration},
  author={Y. Fukui and O. Hashimoto and T. Sanui and T. Oono and H. Koga and M. Abe and A. Inayoshi and M. Noda and M. Oike and T. Shirai and T. Sasazuki},
  journal={Nature},
  year={2001},
  volume={412},
  pages={826-831}
}
Cell migration is a fundamental biological process involving membrane polarization and cytoskeletal dynamics, both of which are regulated by Rho family GTPases. Among these molecules, Rac is crucial for generating the actin-rich lamellipodial protrusion, a principal part of the driving force for movement. The CDM family proteins, Caenorhabditis elegans CED-5, human DOCK180 and Drosophila melanogaster Myoblast City (MBC), are implicated to mediate membrane extension by functioning upstream of… Expand
The CDM protein DOCK2 in lymphocyte migration.
Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing.
Dedicator of Cytokinesis 2 in Cell Signaling Regulation and Disease Development
Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1
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