Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

@article{Fukui2001HaematopoieticCC,
  title={Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration},
  author={Yoshinori Fukui and Osamu Hashimoto and Terukazu Sanui and Takamasa Oono and Hironori Koga and Masaaki Abe and Ayumi Inayoshi and Mayuko Noda and Masahiro Oike and Toshikazu Shirai and Takehiko Sasazuki},
  journal={Nature},
  year={2001},
  volume={412},
  pages={826-831}
}
Cell migration is a fundamental biological process involving membrane polarization and cytoskeletal dynamics, both of which are regulated by Rho family GTPases. Among these molecules, Rac is crucial for generating the actin-rich lamellipodial protrusion, a principal part of the driving force for movement. The CDM family proteins, Caenorhabditis elegans CED-5, human DOCK180 and Drosophila melanogaster Myoblast City (MBC), are implicated to mediate membrane extension by functioning upstream of… CONTINUE READING
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