Haem, haem oxygenase and ferritin in vascular endothelial cell injury.

@article{Balla2003HaemHO,
  title={Haem, haem oxygenase and ferritin in vascular endothelial cell injury.},
  author={J{\'o}zsef Balla and Gregory Vercellotti and K Lalitendra Nath and Akihiro Yachie and Emőke Nagy and John W. Eaton and Gy{\"o}rgy Balla},
  journal={Molecular nutrition & food research},
  year={2003},
  volume={49 11},
  pages={1030-43}
}
Iron-derived reactive oxygen species (ROS) are implicated in the pathogenesis of numerous vascular disorders including atherosclerosis, microangiopathic haemolytic anaemia, vasculitis and reperfusion injury. One abundant source of redox-active iron is haem, which is inherently dangerous when released from intracellular haem proteins. The present review concerns the likely involvement of haem in vascular endothelial cell damage and the strategies used by endothelium to minimize such damage… CONTINUE READING