Hachinski's ischemic score and the diagnosis of vascular dementia: A review

@article{Pantoni2006HachinskisIS,
  title={Hachinski's ischemic score and the diagnosis of vascular dementia: A review},
  author={Leonardo Pantoni and Domenico Inzitari},
  journal={The Italian Journal of Neurological Sciences},
  year={2006},
  volume={14},
  pages={539-546}
}
The Hachinski ischemic score (HIS) scale is a simple clinical tool proposed and currently used for differentiating types of dementia (primary degenerative, vascular or multi-infarct, mixed type). Criteria for rating the items of the HIS were never given, or inter-observer reliability in applying it has never been tested. However, the studies which estimated the validity of this scale in predicting the true diagnosis (clinical/CT or neuropathological definition) demonstrated acceptable… 
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35 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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35 Citations

Comments on Hachinski's ischemic score for vascular dementia
TLDR
In the authors' opinion, the conclusion that the HIS can be considered as having acceptable validity is not justified, and it is misleading for both clinicians and researchers.
Validation of clinical criteria for possible vascular dementia in the oldest-old
Optimizing the Hachinski Ischemic Scale.
TLDR
Two optimized HIS versions were identified that classify patients with vascular dementia vs those with nonvascular dementia as well as or more accurately than the original HIS instrument.
Optimizing the Hachinski ischemic scale
Démences vasculaires et démences mixtes
Clinical utility of cognitive screening instruments in dementia patients of neurology OPD (Memory Clinic) in Eastern Uttar Pradesh, India
TLDR
MoCA, ACE, and EASI tools have good capability to detect most patients with cognitive impairments and are sensitive to predict probable cases of dementia, therefore can be used as an efficient diagnostic tool in quick screening of cognitive impairment.
Clinical Correlates of Hachinski Ischemic Score and Vascular Factors in Cognitive Function of Elderly
TLDR
The Hachinski ischemic score seemed to contribute to the evaluation of the quantity of vascular factors and to the prediction of status of cognitive function in elderly community.
Cerebrolysin for vascular dementia.
TLDR
This is the first update of a review of Cerebrolysin in vascular dementia to add new studies from the international literature and employ contemporary methods for appraising the strength of the evidence.
Investigation of risk factors for the conversion of mild cognitive impairment to dementia
TLDR
Age and worsening attention but not depression in MCI patients were independently associated with the progression of dementia in a 6-year follow-up period.
Cerebrolysin for vascular dementia.
TLDR
Cerebrolysin may have positive effects on cognitive function and global function in elderly patients with vascular dementia of mild to moderate severity, but there is still insufficient evidence to recommend Cere Brolysin as a routine treatment for vascular dementia.
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References

SHOWING 1-10 OF 43 REFERENCES
Prospective neuropathological validation of Hachinski's Ischaemic Score in dementias.
TLDR
The uncritical application of Hachinski's Ischaemic Score to large samples in epidemiological studies may cause incorrect labelling of a significant proportion of patients with primary degenerative dementia as vascular dementia, based on observations of long-term inpatients and depend on neuropathological criteria.
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TLDR
A modified ischemic score consisting of five items (abrupt onset; history of strokes; focal symptoms; focal signs; focal (single or multiple) CT-low density areas) is proposed as a useful tool in the differential diagnosis between SDAT and MID.
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TLDR
The results show that the differentiation between the major types of presenile dementia can be achieved by a systematic rating of the clinical features.
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TLDR
With neuropathological diagnosis as the point of reference, the accuracy of clinical diagnosis was studied in a series of 58 demented patients, and the value of Hachinski's Ischaemic Score in differentiating between Alzheimer's disease and vascular dementias was demonstrated.
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TLDR
This study is a cluster by case analysis of the data from Hachinski's original report that provides support for those clinicopathologic studies that have found Hachanski's ischemic score of value.
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TLDR
Criteria for the diagnosis of ischemic vascular dementia (IVD) broaden the conceptualization of vascular dementia, include the results of neuroimaging studies, emphasize the importance of neuropathologic confirmation, refine nosology, and identify areas that require further research.
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TLDR
This critical analysis of representative clinical studies and articles published over the past two decades reveals important drawbacks in methodologic approaches and interpretation of data which seriously undermine confidence in making the clinical distinction between PDD and MID.
Pathological verification of ischemic score in differentiation of dementias
Fourteen case histories of persons who had a histological diagnosis of either senile dementia of the Alzheimer type, multiinfarct dementia, or a mixed dementia composed of these two types and who…
Vascular dementia
TLDR
These criteria for the diagnosis of vascular dementia are intended as a guide for case definition in neuroepidemiologic studies, stratified by levels of certainty (definite, probable, and possible).
Differential diagnosis between Alzheimer's disease and vascular dementia: evaluation of common clinical methods
TLDR
Quantitative neuropsychology, EEC, routine cerebrospinal fluid and other laboratory investigations, including serum glucose and plasma lipids, seem to be less valuable and ischemic scores seemed also to be useful in the differential diagnosis between AD and vascular dementia.
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