Habituation of acoustic startle is disrupted by psychotomimetic drugs: differential dependence on dopaminergic and nitric oxide modulatory mechanisms

@article{Klamer2004HabituationOA,
  title={Habituation of acoustic startle is disrupted by psychotomimetic drugs: differential dependence on dopaminergic and nitric oxide modulatory mechanisms},
  author={Daniel Klamer and Erik P{\aa}lsson and Aron Revesz and J{\"o}rgen A. Engel and Lennart Dipl Ing Svensson},
  journal={Psychopharmacology},
  year={2004},
  volume={176},
  pages={440-450}
}
  • Daniel Klamer, Erik Pålsson, +2 authors Lennart Dipl Ing Svensson
  • Published in Psychopharmacology 2004
  • Psychology, Medicine
  • RationaleA deficit in attention and information processing has been considered a central feature in schizophrenia, which might lead to stimulus overload and cognitive fragmentation. It has been shown that patients with schizophrenia display a relative inability to gate incoming stimuli. Thus, patients repeatedly subjected to acoustic startle-eliciting stimuli habituate less to these stimuli than controls. Furthermore, schizophrenia-like symptoms can be induced by pharmacological manipulations… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 28 CITATIONS

    Information processing deficits and nitric oxide signalling in the phencyclidine model of schizophrenia

    VIEW 6 EXCERPTS
    CITES BACKGROUND, RESULTS & METHODS

    Preclinical animal anxiety research – flaws and prejudices

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Alzheimer’s disease in the zebrafish: where can we take it?

    VIEW 1 EXCERPT
    CITES RESULTS

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 63 REFERENCES

    Seroquel restores sensorimotor gating in phencyclidine-treated rats.

    VIEW 14 EXCERPTS
    HIGHLY INFLUENTIAL