Habituation and sensitization of acoustic startle: opposite influences of dopamine D1 and D2-family receptors.

@article{Halberstadt2009HabituationAS,
  title={Habituation and sensitization of acoustic startle: opposite influences of dopamine D1 and D2-family receptors.},
  author={Adam L. Halberstadt and Mark A. Geyer},
  journal={Neurobiology of learning and memory},
  year={2009},
  volume={92 2},
  pages={243-8}
}
The startle response evoked by repeated presentation of a loud acoustic stimulus is regulated by the independent processes of sensitization and habituation. While schizophrenia is associated with information processing impairments, there is conflicting evidence regarding the existence of habituation deficits in schizophrenic patients. Recent clinical evidence, however, indicates that patients with schizophrenia display exaggerated startle sensitization and diminished habituation. Given the… CONTINUE READING