Habitual abortion and translocation (22q;22q): unexpected transmission from a mother to her phenotypically normal daughter.

@article{Kirkels1980HabitualAA,
  title={Habitual abortion and translocation (22q;22q): unexpected transmission from a mother to her phenotypically normal daughter.},
  author={Vincent G. H. J. Kirkels and Th. W. J. Hustinx and Jacques Scheres},
  journal={Clinical genetics},
  year={1980},
  volume={18 6},
  pages={456-61}
}
This paper describes the unexpected transmission of a translocation (22;22)(p13;q11) from a mother to her phenotypically normal daughter (the proband). Both women had had multiple abortions. No signs of mosaicism with respect to chromosome No. 22 were found in the proband or in her mother. Until now, it has been generally assumed that carriers of a 22/22 translocation will have only abnormal conceptuses. The transmission of this translocation from a balanced carrier to a phenotypically normal… CONTINUE READING

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