Ha-ras overexpression mediated cell apoptosis in the presence of 5-fluorouracil.

  title={Ha-ras overexpression mediated cell apoptosis in the presence of 5-fluorouracil.},
  author={Ya-Shih Tseng and C. Tzeng and Allen Wen-hsiang Chiu and Chia-Hsiang Lin and S. -J. Won and I-Chien Wu and Hsiao-Sheng Liu},
  journal={Experimental cell research},
  volume={288 2},
By using a mouse NIH3T3 derivate designed 7-4 harboring the inducible Ha-ras oncogene, we demonstrated the close relationship between Ha-ras expression level and sensitization of 5-flurouracil (5-FU)-treated cells. Further studies revealed that the cells susceptible to 5-FU treatment died of apoptosis, which was demonstrated by caspase-3 activation, loss of mitochondria membrane potential (MMP), and DNA fragmentation. The 7-4 cells coexpressing dominant negative Ras (Ras(Asn17)), dominant… CONTINUE READING

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