Ha-ras overexpression mediated cell apoptosis in the presence of 5-fluorouracil.

@article{Tseng2003HarasOM,
  title={Ha-ras overexpression mediated cell apoptosis in the presence of 5-fluorouracil.},
  author={Ya-Shih Tseng and C. Tzeng and Allen Wen-hsiang Chiu and Chia-Hsiang Lin and S. -J. Won and I-Chien Wu and Hsiao-Sheng Liu},
  journal={Experimental cell research},
  year={2003},
  volume={288 2},
  pages={403-14}
}
By using a mouse NIH3T3 derivate designed 7-4 harboring the inducible Ha-ras oncogene, we demonstrated the close relationship between Ha-ras expression level and sensitization of 5-flurouracil (5-FU)-treated cells. Further studies revealed that the cells susceptible to 5-FU treatment died of apoptosis, which was demonstrated by caspase-3 activation, loss of mitochondria membrane potential (MMP), and DNA fragmentation. The 7-4 cells coexpressing dominant negative Ras (Ras(Asn17)), dominant… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
12 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…