Ha-ras hypervariable alleles in myelodysplasia

  title={Ha-ras hypervariable alleles in myelodysplasia},
  author={Swee Lay Thein and David Oscier and Jonathan Flint and J. S. Wainscoat},
The somatic mutation of one of the ras oncogenes is now considered to be a critical step in the pathogenesis of many tumours1,2. Circumstantial evidence also suggests that some individuals may be genetically predisposed to malignancy3 and a general method used to analyse such disease susceptibility is the study of restriction fragment length polymorphisms (RFLPs) at particular loci4,5. The Harvey ras (Ha-ras) locus includes a hypervariable region (HVR) which consists of a series of 28-base-pair… CONTINUE READING
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