Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo

@article{Hamilton1998HarasAN,
  title={Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo},
  author={Mark Hamilton and Alan Wolfman},
  journal={Oncogene},
  year={1998},
  volume={16},
  pages={1417-1428}
}
The Ras GTPases function as molecular switches, regulating a multiplicity of biological events. However the contribution, if any, of a specific c-Ras isoform (Ha-, N-, or Ki-ras A or B) in the regulation of a given biological or biochemical process, is unknown. Murine C3H10T1/2 fibroblasts transformed with activated (G12V)Ha-ras or (Q61K)N-ras proliferate in serum-free media and have constitutive MAPK activity. The growth factor antagonist, suramin, inhibited the serum-independent proliferation… CONTINUE READING

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