Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.

Abstract

It is not yet clear whether some polymorphic variants of the Ha-ras-1 gene confer genetic predisposition to cancer. However, recent data on myelodysplasia and lung cancer are controversial. To clarify this point, 62 colorectal adenocarcinoma patients were examined for the Ha-ras-1 gene restriction fragment length polymorphism and results were compared with those of 108 healthy blood donors. No Ha-ras-1 polymorphic variants specifically associated with the cancer patients were detected. However, a specific genotype was significantly more frequent in the healthy donors than in the cancer patients (16% versus 5%), suggesting an interaction between the two alleles of the gene.

DOI: 10.1038/bjc.1987.143

Extracted Key Phrases

5 Figures and Tables

Statistics

05001000'91'94'97'00'03'06'09'12'15
Citations per Year

336 Citations

Semantic Scholar estimates that this publication has 336 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{CeccheriniNelli1987Haras1RF, title={Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.}, author={Luca Ceccherini-Nelli and Valli De Re and Alessandra Viel and G. Molaro and Loredana Zilli and Celeste Clemente and Mauro Boiocchi}, journal={British Journal of Cancer}, year={1987}, volume={56}, pages={1 - 5} }