Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.


It is not yet clear whether some polymorphic variants of the Ha-ras-1 gene confer genetic predisposition to cancer. However, recent data on myelodysplasia and lung cancer are controversial. To clarify this point, 62 colorectal adenocarcinoma patients were examined for the Ha-ras-1 gene restriction fragment length polymorphism and results were compared with those of 108 healthy blood donors. No Ha-ras-1 polymorphic variants specifically associated with the cancer patients were detected. However, a specific genotype was significantly more frequent in the healthy donors than in the cancer patients (16% versus 5%), suggesting an interaction between the two alleles of the gene.

DOI: 10.1038/bjc.1987.143

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@article{CeccheriniNelli1987Haras1RF, title={Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.}, author={Luca Ceccherini-Nelli and Valli De Re and Alessandra Viel and G. Molaro and Loredana Zilli and Celeste Clemente and Mauro Boiocchi}, journal={British Journal of Cancer}, year={1987}, volume={56}, pages={1 - 5} }