Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

@article{Bintruy1991HaRasAC,
  title={Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain},
  author={Bernard Bin{\'e}truy and Tod Smeal and Michael Karin},
  journal={Nature},
  year={1991},
  volume={351},
  pages={122-127}
}
Ha-Ras augments c-Jun-mediated transactivation by potentiating the activity of the c-Jun activation domain. Ha-Ras also causes a corresponding increase in phosphorylation of specific sites in that part of the c-Jun protein. A Ha-Ras-induced protein kinase cascade resulting in hyperphosphorylation of the c-Jun activation domain could explain how these oncoproteins cooperate to transform rat embryo fibroblasts. 

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