HYST: a hybrid set-based test for genome-wide association studies, with application to protein-protein interaction-based association analysis.

@article{Li2012HYSTAH,
  title={HYST: a hybrid set-based test for genome-wide association studies, with application to protein-protein interaction-based association analysis.},
  author={Miao-Xin Li and Johnny S. H. Kwan and Pak Chung Sham},
  journal={American journal of human genetics},
  year={2012},
  volume={91 3},
  pages={478-88}
}
The extended Simes' test (known as GATES) and scaled chi-square test were proposed to combine a set of dependent genome-wide association signals at multiple single-nucleotide polymorphisms (SNPs) for assessing the overall significance of association at the gene or pathway levels. The two tests use different strategies to combine association p values and can outperform each other when the number of and linkage disequilibrium between SNPs vary. In this paper, we introduce a hybrid set-based test… CONTINUE READING
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