HYPERSENSITIVITY OF MELATONIN SUPPRESSION IN RESPONSE TO LIGHT IN PATIENTS WITH DELAYED SLEEP PHASE SYNDROME*

@article{Aoki2001HYPERSENSITIVITYOM,
  title={HYPERSENSITIVITY OF MELATONIN SUPPRESSION IN RESPONSE TO LIGHT IN PATIENTS WITH DELAYED SLEEP PHASE SYNDROME*},
  author={Harusuke Aoki and Yuji Ozeki and Naoto Yamada},
  journal={Chronobiology International},
  year={2001},
  volume={18},
  pages={263 - 271}
}
Patients with delayed sleep phase syndrome (DSPS) experiencea chronic mismatch between the usual daily schedule required by the individual'senvironment and their circadian sleep-wake pattern, resulting in major academic,work, and social problems. Although functional abnormalities of the circadianpacemaker system have been reported in patients with DSPS, the etiology ofDSPS has not been fully elucidated. One hypothesis proposed to explain whypatients with DSPS fail to synchronize their 24h sleep… 
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133 Citations

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It is found that circadian rhythms are less stable, and sleep is less regular in patients with DSWPD, which could contribute to etiology of the disorder.

The pupillary light reflex distinguishes between circadian and non-circadian delayed sleep phase disorder (DSPD) phenotypes in young adults

TLDR
The potential for the pupillary light reflex to clinically differentiate between DSPD patients with normal vs. delayed circadian timing relative to desired bedtime is supported, without the need for costly and time-consuming circadian assessments.

Circadian rhythm sleep disorders: characteristics and entrainment pathology in delayed sleep phase and non-24-h sleep-wake syndrome.

Circadian Rhythm Disorders in Childhood

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Pediatric categories of subjects that are at risk of developing circadian disorders, such as those with a developmental disability, autism, attention-deficit hyperactivity disorders, and mood disorders, are investigated and clinical features of each sleep circadian disorder are discussed together with the recommended treatment.

The etiology of delayed sleep phase disorder.

Efficacy and safety of supplemental melatonin for delayed sleep–wake phase disorder in children: an overview

Personality differences in patients with delayed sleep-wake phase disorder and non-24-h sleep-wake rhythm disorder relative to healthy sleepers.

Inter-Individual Differences in Neurobehavioural Impairment following Sleep Restriction Are Associated with Circadian Rhythm Phase

TLDR
It is demonstrated that the phase of an individual’s circadian system is an important variable in predicting the degree of neurobehavioural performance impairment in the hours after waking following sleep restriction, and confirms that other factors influencing performance decrements require further investigation.
...

References

SHOWING 1-10 OF 18 REFERENCES

Evaluating the role of melatonin in the long-term treatment of delayed sleep phase syndrome (DSPS).

TLDR
Examination of the efficiency of melatonin treatment in a relatively large population of DSPS subjects by means of subjective reports found that the pretreatment falling asleep and waking times of patients in whom the changes were retained for a relatively long period of time were significantly earlier than those of patients whose relapse was immediate.

The delayed sleep phase syndrome: clinical and investigative findings in 14 subjects.

TLDR
The syndrome causes severe disruption to education, work and family life, and different patterns of sleep phase delay seen in the syndrome include stable, progressive, irregular and non-24 hour sleep-wake cycles.

Chronotherapy: resetting the circadian clocks of patients with delayed sleep phase insomnia.

TLDR
A brief drug-free rescheduling treatment for Delayed Sleep Phase insomnia, a syndrome characterized by sleep-onset insomnia with difficulty in morning awakening, which was designed to reset patients' biological clocks by the phase delay route.

Treatment of delayed sleep phase syndrome.

Prolonged interval from body temperature nadir to sleep offset in patients with delayed sleep phase syndrome.

TLDR
The inability of the patients with DSPS to normally phase-advance their circadian rhythm may be a consequence of masking of the advance portion of their phase-response curve by the last hours of their prolonged sleep episodes.

Phase-shifting effects of bright morning light as treatment for delayed sleep phase syndrome.

TLDR
It is found that 2 h of bright light exposure in the morning together with light restriction in the evening successfully phase advanced circadian rhythms of core body temperature and multiple sleep latencies in patients with delayed sleep phase syndrome.

Delayed sleep phase syndrome. A chronobiological disorder with sleep-onset insomnia.

TLDR
A new syndrome called "delayed sleep phase insomnia" is described, which is proposed to be a disorder of the circadian sleep-wake rhythm in which the "advance" portion of the phase response curve is small.

Circadian sleep regulation in the absence of light perception: chronic non-24-hour circadian rhythm sleep disorder in a blind man with a regular 24-hour sleep-wake schedule.

TLDR
The findings in this blind man suggest that both his sleep structure and the severity of his daily sleep disruption are directly related to circadian phase and his circadian pacemaker cannot be entrained by periodic daily exposure to nonphotic time cues, including a very regular 24-hour sleep-wake schedule.

Body temperature monitoring in subjects with delayed sleep phase syndrome.

TLDR
It is concluded that in DSPS there is a weakened mechanism of entrainment similar to that in non-24-hour sleep-wake syndrome.

Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle.

TLDR
Exposure to bright light can indeed reset the human circadian pacemaker, which controls daily variations in physiologic, behavioral, and cognitive function, as indicated by recordings of body temperature and cortisol secretion.