HYAL1 and HYAL2 Inhibit Tumour Growth In Vivo but Not In Vitro

@article{Wang2008HYAL1AH,
  title={HYAL1 and HYAL2 Inhibit Tumour Growth In Vivo but Not In Vitro},
  author={Fuli Wang and Elvira V. Grigorieva and Jingfeng Li and Vera N. Senchenko and Tatiana V. Pavlova and Ekaterina A. Anedchenko and Anna V. Kudryavtseva and Alexander Tsimanis and Debora Angeloni and M. I. Lerman and Vladimir Kashuba and George Klein and Eugene R. Zabarovsky},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={1392 - 1399}
}
BACKGROUND We identified two 3p21.3 regions (LUCA and AP20) as most frequently affected in lung, breast and other carcinomas and reported their fine physical and gene maps. It is becoming increasingly clear that each of these two regions contains several TSGs. Until now TSGs which were isolated from AP20 and LUCA regions (e.g.G21/NPRL2, RASSF1A, RASSF1C, SEMA3B, SEMA3F, RBSP3) were shown to inhibit tumour cell growth both in vitro and in vivo. METHODOLOGY/PRINCIPAL FINDINGS The effect of… CONTINUE READING