HY-Specific Induced Regulatory T Cells Display High Specificity and Efficacy in the Prevention of Acute Graft-versus-Host Disease.

@article{Li2015HYSpecificIR,
  title={HY-Specific Induced Regulatory T Cells Display High Specificity and Efficacy in the Prevention of Acute Graft-versus-Host Disease.},
  author={Jun Li and Jessica Lauren Heinrichs and Kelley M.K. Haarberg and Kenrick Semple and Anandharaman Veerapathran and Chang Liu and Claudio M. Anasetti and Xue-zhong Yu},
  journal={Journal of immunology},
  year={2015},
  volume={195 2},
  pages={
          717-25
        }
}
Naturally derived regulatory T cells (Tregs) may prevent graft-versus-host disease (GVHD) while preserving graft-versus-leukemia (GVL) activity. However, clinical application of naturally derived regulatory T cells has been severely hampered by their scarce availability and nonselectivity. To overcome these limitations, we took alternative approaches to generate Ag-specific induced Tregs (iTregs) and tested their efficacy and selectivity in the prevention of GVHD in preclinical models of bone… CONTINUE READING
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