HX-1171, a Novel Nrf2 Activator, Induces NQO1 and HMOX1 Expression.

  title={HX-1171, a Novel Nrf2 Activator, Induces NQO1 and HMOX1 Expression.},
  author={Jimin Kim and Su-Hyun Shin and Young-Eun Ko and Tokutaro Miki and Heung-Mo Bae and Jong-koo Kang and Jae Wha Kim},
  journal={Journal of cellular biochemistry},
  volume={118 10},
HX-1171 (1-O-hexyl-2,3,5-trimethylhydroquinone) is a novel synthesized vitamin E derivative, which reportedly has positive effects on various diseases and conditions, such as liver fibrosis, hepatic cirrhosis, and cancer. In this study, we analyzed the transcriptional activity induced by HX-1171. Results from reverse transcription polymerase chain reaction and promoter assays reveal that HX-1171 increased the expression of NQO1 and HMOX1, encoding antioxidant-related enzymes, in A549 human lung… CONTINUE READING
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