HUWE1 ubiquitinates MyoD and targets it for proteasomal degradation.

@article{Noy2012HUWE1UM,
  title={HUWE1 ubiquitinates MyoD and targets it for proteasomal degradation.},
  author={Tahel Noy and Oded Suad and Daniel Taglicht and Aaron Ciechanover},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={418 2},
  pages={408-13}
}
MyoD is a tissue-specific transcriptional activator that acts as a master switch for muscle development. It activates a broad array of muscle-specific genes, which leads to conversion of proliferating myoblasts into mature myotubes. The ubiquitin proteasome system (UPS) plays an important role in controlling MyoD. Both its N-terminal residue and internal lysines can be targeted by ubiquitin, and both modifications appear to direct it for proteasomal degradation. The protein is short-lived and… CONTINUE READING

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