HUMAN ACETYLATION POLYMORPHISM.

@article{Evans1964HUMANAP,
  title={HUMAN ACETYLATION POLYMORPHISM.},
  author={Dennis A. Evans and Thomas A. White},
  journal={The Journal of laboratory and clinical medicine},
  year={1964},
  volume={63},
  pages={
          394-403
        }
}
Abstract Sulfamethazine acetylation is polymorphic in human populations and the isoniazid inactivator polymorphism is due to the same acetylation phenomenon. Studies performed with human liver homogenates reveal that the polymorphism lies in the activity of the enzyme acetyl transferase, which transfers acetyl groups from acetyl-coenzyme A to the acceptor drug molecule. Hydralazine has also been shown to be an acceptor drug molecule which is subject to the same polymorphic acetylation… CONTINUE READING

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Polymorphic acetylation of sulphadimidine in normal and uraemic man

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