HTRA1 promoter polymorphism predisposes Japanese to age-related macular degeneration

  title={HTRA1 promoter polymorphism predisposes Japanese to age-related macular degeneration},
  author={Tsunehiko Yoshida and Andrew T. Dewan and Hong Zhang and Ryosuke Sakamoto and Haru Okamoto and Masayoshi Minami and Minoru Obazawa and Atsushi Mizota and Minoru Tanaka and Yoshihiro Saito and Ikue Takagi and Josephine Hoh and Takeshi Iwata},
  journal={Molecular Vision},
  pages={545 - 548}
PURPOSE To study the effect of candidate single nucleotide polymorphisms (SNPs) on chromosome 10q26, recently shown to be associated with wet age-related macular degeneration (AMD) in Chinese and Caucasian cohorts, in a Japanese cohort. METHODS Using genomic DNA isolated from peripheral blood of wet AMD cases and age-matched controls, we genotyped two SNPs, rs10490924, and rs11200638, on chromosome 10q26, 6.6 kb and 512 bp upstream of the HTRA1 gene, respectively, using temperature gradient… CONTINUE READING


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