HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis.

  title={HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis.},
  author={William Goodyer and Susanne Kaitna and Florence Couteau and Jordan D Ward and Simon J. Boulton and Monique C. Zetka},
  journal={Developmental cell},
  volume={14 2},
Repair of the programmed meiotic double-strand breaks (DSBs) that initiate recombination must be coordinated with homolog pairing to generate crossovers capable of directing chromosome segregation. Chromosome pairing and synapsis proceed independently of recombination in worms and flies, suggesting a paradoxical lack of coregulation. Here, we find that the meiotic axis component HTP-3 links DSB formation with homolog pairing and synapsis. HTP-3 forms complexes with the DSB repair components MRE… CONTINUE READING
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A component of C

F. Couteau, K. Nabeshima, A. M. Villeneuve, M. Zetka
elegans meiotic chromosome axes at the interface of homolog alignment, synapsis, nuclear reorganization, and recombination. Curr. Biol. 14, 585–592. • 2004
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