HTLV-I infection: a dynamic struggle between viral persistence and host immunity.

@article{Lim2014HTLVIIA,
  title={HTLV-I infection: a dynamic struggle between viral persistence and host immunity.},
  author={Aaron G. Lim and Philip K. Maini},
  journal={Journal of theoretical biology},
  year={2014},
  volume={352},
  pages={92-108}
}
Human T-lymphotropic virus type I (HTLV-I) causes chronic infection for which there is no cure or neutralising vaccine. HTLV-I has been clinically linked to the development of adult T-cell leukaemia/lymphoma (ATL), an aggressive blood cancer, and HAM/TSP, a progressive neurological and inflammatory disease. Infected individuals typically mount a large, persistently activated CD8(+) cytotoxic T-lymphocyte (CTL) response against HTLV-I-infected cells, but ultimately fail to effectively eliminate… CONTINUE READING
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