HTLV-1 Tax: regulation of gene expression and disease.

  title={HTLV-1 Tax: regulation of gene expression and disease.},
  author={Mitsuaki Yoshida},
  journal={Trends in microbiology},
  volume={1 4},
The human T cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes adult T cell leukemia and the neurological disorder tropical spastic paraparesis. Pathology apparently results from the activities of the Tax protein, which trans-activates the expression of viral and cellular genes by binding to various enhancer-binding proteins needed for transcription. This ultimately results in cell transformation, immortalization and disease.