HTLV-1 Integration into Transcriptionally Active Genomic Regions Is Associated with Proviral Expression and with HAM/TSP

@article{Meekings2008HTLV1II,
  title={HTLV-1 Integration into Transcriptionally Active Genomic Regions Is Associated with Proviral Expression and with HAM/TSP},
  author={Kiran N. Meekings and Jeremy N Leipzig and Frederic D. Bushman and Graham P Taylor and Charles R. M. Bangham},
  journal={PLoS Pathogens},
  year={2008},
  volume={4},
  pages={e234 - 7768}
}
Human T-lymphotropic virus type 1 (HTLV-1) causes leukaemia or chronic inflammatory disease in approximately 5% of infected hosts. The level of proviral expression of HTLV-1 differs significantly among infected people, even at the same proviral load (proportion of infected mononuclear cells in the circulation). A high level of expression of the HTLV-1 provirus is associated with a high proviral load and a high risk of the inflammatory disease of the central nervous system known as HTLV-1… CONTINUE READING
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