HTLV-1 HBZ protein inhibits IRF3-mediated innate immune responses

Abstract

The bZIP factor (HBZ) is an HTLV-1 regulatory protein encoded by anti-sense transcription of the HTLV-1 genome. HBZ mRNA expression correlates with clinical disability in HAM/TSP patients – and can be reversed by interferon (IFN) therapy. Sporadic evidence suggests that HBZ may have a negative role on interferon signalling. Activation of IRF3-dependent IFN… (More)
DOI: 10.1186/1742-4690-8-S1-A99

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