HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1

@article{Uchimura2005HSulf2AE,
  title={HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1},
  author={Kenji Uchimura and Megumi Morimoto-Tomita and Annette Bistrup and Jessica J Li and Malcolm Lyon and John Thomas Gallagher and Zena Werb and Stuart Rosen},
  journal={BMC Biochemistry},
  year={2005},
  volume={7},
  pages={2 - 2}
}
BackgroundHeparin/heparan sulfate (HS) proteoglycans are found in the extracellular matrix (ECM) and on the cell surface. A considerable body of evidence has established that heparin and heparan sulfate proteoglycans (HSPGs) interact with numerous protein ligands including fibroblast growth factors, vascular endothelial growth factor (VEGF), cytokines, and chemokines. These interactions are highly dependent upon the pattern of sulfation modifications within the glycosaminoglycan chains. We… CONTINUE READING
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