HSV ICP0 recruits USP7 to modulate TLR-mediated innate response.

@article{Daubeuf2009HSVIR,
  title={HSV ICP0 recruits USP7 to modulate TLR-mediated innate response.},
  author={S. Daubeuf and Divyendu Singh and Yaohong Tan and Hongiu Liu and H. Federoff and W. Bowers and K. Tolba},
  journal={Blood},
  year={2009},
  volume={113 14},
  pages={
          3264-75
        }
}
Pattern recognition receptors represent the first line of defense against invading pathogens. Herpes simplex virus (HSV) encodes multiple ligands detected by these receptors, yet persists in the majority of infected individuals indicating a breakdown in host defense against the virus. Here we identify a novel mechanism through which HSV immediate-early protein ICP0 inhibits TLR-dependent inflammatory response by blocking NF-kappaB and JNK activation downstream of TLR signal activation. This… Expand
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