HSV Glycoprotein B Fusion Loop Architecture and Mechanisms of Fusion Inhibition

@inproceedings{Hannah2008HSVGB,
  title={HSV Glycoprotein B Fusion Loop Architecture and Mechanisms of Fusion Inhibition},
  author={Brian P. Hannah},
  year={2008}
}
Herpes simplex virus (HSV) entry into host cells requires the function of the viral envelope glycoprotein (g) B in concert with three other envelope proteins, namely gD and the complex of gH/gL. Glycoprotein D functions in receptor binding and communicates an activation signal to gB and/or to gH/gL to carry out fusion between the viral envelope and cell membranes to release the capsid into the cell and begin the replication process. In this dissertation, I present a detailed mutagenic analysis… CONTINUE READING

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