HSV-2 Infection of Dendritic Cells Amplifies a Highly Susceptible HIV-1 Cell Target

  title={HSV-2 Infection of Dendritic Cells Amplifies a Highly Susceptible HIV-1 Cell Target},
  author={Elena Martinelli and Hugo Tharinger and Ines Frank and James Arthos and Michael J. Piatak and Jeffrey D Lifson and James Blanchard and Agegnehu Gettie and Melissa Robbiani},
  booktitle={PLoS pathogens},
Herpes simplex virus type 2 (HSV-2) increases the risk of HIV-1 infection and, although several reports describe the interaction between these two viruses, the exact mechanism for this increased susceptibility remains unclear. Dendritic cells (DCs) at the site of entry of HSV-2 and HIV-1 contribute to viral spread in the mucosa. Specialized DCs present in the gut-associated lymphoid tissues produce retinoic acid (RA), an important immunomodulator, able to influence HIV-1 replication and a key… CONTINUE READING


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