HSV-1 tegument protein and the development of its genome editing technology

  title={HSV-1 tegument protein and the development of its genome editing technology},
  author={Xingli Xu and Yanchun Che and Qi-han Li},
  booktitle={Virology Journal},
Herpes simplex virus 1 (HSV-1) is composed of complex structures primarily characterized by four elements: the nucleus, capsid, tegument and envelope. The tegument is an important viral component mainly distributed in the spaces between the capsid and the envelope. The development of viral genome editing technologies, such as the identification of temperature-sensitive mutations, homologous recombination, bacterial artificial chromosome, and the CRISPR/Cas9 system, has been shown to largely… CONTINUE READING


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