HSV-1 ICP27 suppresses NF-kappaB activity by stabilizing IkappaBalpha.

  title={HSV-1 ICP27 suppresses NF-kappaB activity by stabilizing IkappaBalpha.},
  author={Jin Chul Kim and Soo Yun Lee and Sang Young Kim and Jeong Ki Kim and Hye Jin Kim and Hee Min Lee and Mi Sun Choi and Jung Sun Min and Mi Jee Kim and Hyang Soon Choi and Jeong Keun Ahn},
  journal={FEBS letters},
  volume={582 16},
Nuclear factor kappaB (NF-kappaB) is associated with the transcriptional activation of genes encoding chemokines, adhesion molecules, cytokines, and anti-apoptotic proteins, which are key components in immune responses and viral infection. Many viruses modulate NF-kappaB through numerous viral gene products to allow productive infections and immune escape. Here we report that herpes simplex virus-1 infected cell protein 27 (HSV-1 ICP27), an immediate early protein of HSV-1, represses NF-kappaB… CONTINUE READING
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