HSPB1 as a Novel Regulator of Ferroptotic Cancer Cell Death

  title={HSPB1 as a Novel Regulator of Ferroptotic Cancer Cell Death},
  author={Xiaofang Sun and Zhanhui Ou and Min Xie and Rui Kang and Yong Fan and Xiaohua Niu and Haichao Wang and Lizhi Cao and Daolin Tang},
Ferroptosis is an iron-dependent form of non-apoptotic cell death, but its molecular mechanism remains largely unknown. Here, we demonstrate that heat shock protein beta-1 (HSPB1) is a negative regulator of ferroptotic cancer cell death. Erastin, a specific ferroptosis-inducing compound, stimulates heat shock factor 1 (HSF1)-dependent HSPB1 expression in cancer cells. Knockdown of HSF1 and HSPB1 enhances erastin-induced ferroptosis, whereas heat shock pretreatment and overexpression of HSPB1… CONTINUE READING


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