HSP90 and the chaperoning of cancer

@article{Whitesell2005HSP90AT,
  title={HSP90 and the chaperoning of cancer},
  author={Luke Whitesell and Susan Lindquist},
  journal={Nature Reviews Cancer},
  year={2005},
  volume={5},
  pages={761-772}
}
Standing watch over the proteome, molecular chaperones are an ancient and evolutionarily conserved class of proteins that guide the normal folding, intracellular disposition and proteolytic turnover of many of the key regulators of cell growth, differentiation and survival. This essential guardian function is subverted during oncogenesis to allow malignant transformation and to facilitate rapid somatic evolution. Pharmacologically 'bribing' the essential guard duty of the chaperone HSP90 (heat… 
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