HSP70.1 and -70.3 are required for late-phase protection induced by ischemic preconditioning of mouse hearts.

@article{Hampton2003HSP701A,
  title={HSP70.1 and -70.3 are required for late-phase protection induced by ischemic preconditioning of mouse hearts.},
  author={Craig R. Hampton and Akira Shimamoto and Christine L. Rothnie and Jeaneatte Griscavage-Ennis and Albert J. Chong and David J. Dix and Edward D. Verrier and Timothy H. Pohlman},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={285 2},
  pages={
          H866-74
        }
}
We investigated the role of inducible heat shock proteins 70.1 and 70.3 (HSP70.1 and HSP70.3, respectively) in myocardial ischemic preconditioning (IP) in mice. Wild-type (WT) mice and HSP70.1- and HSP70.3-null [HSP70.1/3(-/-)] mice were subjected to IP and examined 24 h later during the late phase of protection. IP significantly increased steady-state levels of HSP70.1 and HSP70.3 mRNA and expression of inducible HSP70 protein in WT myocardium. To assess protection against tissue injury, mice… CONTINUE READING

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