HSP70 is essential to the neuroprotective effect of heat-shock.

  title={HSP70 is essential to the neuroprotective effect of heat-shock.},
  author={Kota Sato and Hidehiko Saito and Norio Matsuki},
  journal={Brain research},
  volume={740 1-2},
Many kinds of injuries induce 72 kDa heat-shock protein (HSP70) in the central nervous system. We investigated the role of HSP70 in promoting the survival of rat hippocampal neurons in primary culture. Heat-shock (42 degrees C for 30 min) significantly increased the number of surviving neurons independently of the initial density of plated cells, suggesting a direct effect on the neurons. Immunohistochemical detection revealed that HSP70 was expressed in virtually all cells six hours after the… CONTINUE READING