HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.

@article{Leu2011HSP70IB,
  title={HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.},
  author={Julia I-Ju Leu and Julia Pimkina and Pooja Pandey and Maureen E Murphy and Donna L. George},
  journal={Molecular cancer research : MCR},
  year={2011},
  volume={9 7},
  pages={936-47}
}
The evolutionarily conserved stress-inducible HSP70 molecular chaperone plays a central role in maintaining protein quality control in response to various forms of stress. Constitutively elevated HSP70 expression is a characteristic of many tumor cells and contributes to their survival. We recently identified the small-molecule 2-phenylethyenesulfonamide (PES) as a novel HSP70 inhibitor. Here, we present evidence that PES-mediated inhibition of HSP70 family proteins in tumor cells results in an… CONTINUE READING