HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.

@article{BudinaKolomets2016HSP70IL,
  title={HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.},
  author={Anna Budina-Kolomets and Marie R. Webster and Julia I-Ju Leu and Matthew L. Jennis and Clemens Krepler and Anastasia Guerrini and Andrew V. Kossenkov and Wei Xu and Giorgos C Karakousis and Lynn Mara Schuchter and Ravi K Amaravadi and Hong Wu and Xiangfan Yin and Yiling Lu and Gordon B. Mills and Xiaowei Xu and Donna L. George and Ashani T Weeraratna and Maureen E Murphy},
  journal={Cancer research},
  year={2016},
  volume={76 9},
  pages={
          2720-30
        }
}
The stress-inducible chaperone protein HSP70 (HSPA1) is implicated in melanoma development, and HSP70 inhibitors exert tumor-specific cytotoxic activity in cancer. In this study, we documented that a significant proportion of melanoma tumors express high levels of HSP70, particularly at advanced stages, and that phospho-FAK (PTK2) and BRAF are HSP70 client proteins. Treatment of melanoma cells with HSP70 inhibitors decreased levels of phospho-FAK along with impaired migration, invasion, and… CONTINUE READING
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