HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.

  title={HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.},
  author={Anna Budina-Kolomets and M. Webster and J. I. Leu and M. Jennis and C. Krepler and A. Guerrini and Andrew V. Kossenkov and W. Xu and G. Karakousis and L. Schuchter and Ravi K Amaravadi and H. Wu and X. Yin and Q. Liu and Y. Lu and G. Mills and X. Xu and D. George and A. Weeraratna and M. Murphy},
  journal={Cancer research},
  volume={76 9},
  • Anna Budina-Kolomets, M. Webster, +17 authors M. Murphy
  • Published 2016
  • Medicine
  • Cancer research
  • The stress-inducible chaperone protein HSP70 (HSPA1) is implicated in melanoma development, and HSP70 inhibitors exert tumor-specific cytotoxic activity in cancer. In this study, we documented that a significant proportion of melanoma tumors express high levels of HSP70, particularly at advanced stages, and that phospho-FAK (PTK2) and BRAF are HSP70 client proteins. Treatment of melanoma cells with HSP70 inhibitors decreased levels of phospho-FAK along with impaired migration, invasion, and… CONTINUE READING
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