HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination.

@article{Wu2009HSP27RI,
  title={HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination.},
  author={Yifan Wu and Junhong Liu and Zhengping Zhang and Huang Huang and Jiayin Shen and Shuang-quan Zhang and Yong Jiang and Lan Luo and Zhimin Yin},
  journal={Cellular signalling},
  year={2009},
  volume={21 1},
  pages={143-50}
}
Heat shock protein 27 (HSP27) is an ubiquitiously expressed protein, which has been mediated in various biological functions. Here, we present a novel mechanism utilized by HSP27 in regulating IL-1beta induced NF-small ka, CyrillicB activation. Both over-expression and RNAi experiments indicate that HSP27 physically interacts with tumor necrosis factor… CONTINUE READING