HSP20 phosphorylation and airway smooth muscle relaxation.

  title={HSP20 phosphorylation and airway smooth muscle relaxation.},
  author={Mariam A. Ba and Cherie A. Singer and Manoj Tyagi and Colleen Brophy and Josh E. Baker and Christine R Cremo and Andrew J Halayko and William T. Gerthoffer},
  journal={Cell health and cytoskeleton},
  volume={2009 1},
HSP20 (HSPB6) is a small heat shock protein expressed in smooth muscles that is hypothesized to inhibit contraction when phosphorylated by cAMP-dependent protein kinase. To investigate this hypothesis in airway smooth muscle (ASM) we showed that HSP20 was constitutively expressed as well as being inducible in cultured hASM cells by treatment with 1 μM isoproterenol or 10 μM salmeterol. In contrast, a mixture of proinflammatory mediators (interleukin-1β, tumor necrosis factor α, and interferon… CONTINUE READING


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