HSF1 protects neurons through a novel trimerization- and HSP-independent mechanism.


Heat shock factor 1 (HSF1) protects neurons from death caused by the accumulation of misfolded proteins. It is believed that this protective effect is mediated by the transcriptional stimulation of genes encoding heat shock proteins (HSPs), a family of chaperones that refold or degrade misfolded proteins. Whether HSF1 is protective when neuronal death is… (More)
DOI: 10.1523/JNEUROSCI.3039-13.2014

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