HSF1 at a glance.

  title={HSF1 at a glance.},
  author={Anniina Vihervaara and Lea Sistonen},
  journal={Journal of cell science},
  volume={127 Pt 2},
Heat shock factor 1 (HSF1) is an evolutionarily highly conserved transcription factor that coordinates stress-induced transcription and directs versatile physiological processes in eukaryotes. The central position of HSF1 in cellular homeostasis has been well demonstrated, mainly through its strong effect in transactivating genes that encode heat shock proteins (HSPs). However, recent genome-wide studies have revealed that HSF1 is capable of reprogramming transcription more extensively than… CONTINUE READING


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