HSF-1–mediated cytoskeletal integrity determines thermotolerance and life span

  title={HSF-1–mediated cytoskeletal integrity determines thermotolerance and life span},
  author={Nathan A. Baird and Peter M. Douglas and Milos Simic and Ana Rodrigues Grant and James J. Moresco and Suzanne C. Wolff and John R. Yates and Gerard Manning and Andrew G Dillin},
The conserved heat shock transcription factor–1 (HSF-1) is essential to cellular stress resistance and life-span determination. The canonical function of HSF-1 is to regulate a network of genes encoding molecular chaperones that protect proteins from damage caused by extrinsic environmental stress or intrinsic age-related deterioration. In Caenorhabditis elegans, we engineered a modified HSF-1 strain that increased stress resistance and longevity without enhanced chaperone induction. This… CONTINUE READING
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