HSA21 Single-Minded 2 (Sim2) Binding Sites Co-Localize with Super-Enhancers and Pioneer Transcription Factors in Pluripotent Mouse ES Cells

@inproceedings{Letourneau2015HSA21S2,
  title={HSA21 Single-Minded 2 (Sim2) Binding Sites Co-Localize with Super-Enhancers and Pioneer Transcription Factors in Pluripotent Mouse ES Cells},
  author={Audrey M Letourneau and Gilda Cobellis and Alexandre Fort and Federico Santoni and Marco Garieri and Emilie Falconnet and Pascale G Ribaux and Anne Vannier and Michel Guipponi and Piero Carninci and Christelle Borel and Stylianos E. Antonarakis},
  booktitle={PloS one},
  year={2015}
}
The HSA21 encoded Single-minded 2 (SIM2) transcription factor has key neurological functions and is a good candidate to be involved in the cognitive impairment of Down syndrome. We aimed to explore the functional capacity of SIM2 by mapping its DNA binding sites in mouse embryonic stem cells. ChIP-sequencing revealed 1229 high-confidence SIM2-binding sites… CONTINUE READING
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