HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex.

@article{Zona2013HRasST,
  title={HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex.},
  author={Laetitia Zona and Joachim Lupberger and Nazha Sidahmed-Adrar and Christine Schweitzer Thumann and Helen J. Harris and Amy A Barnes and Jonathan Florentin and Rajiv G. Tawar and Fei Xiao and Marine Turek and Sarah C. Durand and François H. T. Duong and Markus H Heim and François-Lo{\"i}c Cosset and Ivan Hirsch and Didier Samuel and Laurent Brino and Mirjam B Zeisel and François le Naour and Jane A McKeating and Thomas F Baumert},
  journal={Cell host & microbe},
  year={2013},
  volume={13 3},
  pages={
          302-13
        }
}
Hepatitis C virus (HCV) entry is dependent on coreceptor complex formation between the tetraspanin superfamily member CD81 and the tight junction protein claudin-1 (CLDN1) on the host cell membrane. The receptor tyrosine kinase EGFR acts as a cofactor for HCV entry by promoting CD81-CLDN1 complex formation via unknown mechanisms. We identify the GTPase HRas, activated downstream of EGFR signaling, as a key host signal transducer for EGFR-mediated HCV entry. Proteomic analysis revealed that HRas… CONTINUE READING
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