HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.

@article{Rolny2011HRGIT,
  title={HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.},
  author={Charlotte Rolny and Massimiliano Mazzone and S{\`o}nia Tugues and Damya Laoui and Irja Johansson and Cathy Coulon and Mario Leonardo Squadrito and Inmaculada Segura and Xiujuan Li and Ellen Knevels and Sandra M{\'a}rcia Carvalho Ribeiro Costa and Stefan Vinckier and Tom Dresselaer and Peter {\AA}kerud and Maria de Mol and Henriikka H Salom{\"a}ki and Mia Phillipson and Sabine Wyns and Erik Larsson and Ian Buysschaert and J. Botling and Uwe Himmelreich and Jo A. van Ginderachter and Michele De Palma and Mieke Dewerchin and Lena Claesson-Welsh and Peter Carmeliet},
  journal={Cancer cell},
  year={2011},
  volume={19 1},
  pages={31-44}
}
Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks of malignancy, but their molecular basis and interrelationship remains enigmatic. We report that the host-produced histidine-rich glycoprotein (HRG) inhibits tumor growth and metastasis, while improving chemotherapy. By skewing TAM polarization away from the M2- to a tumor-inhibiting M1-like phenotype, HRG promotes antitumor immune… CONTINUE READING