HPV16 infection of HaCaTs is dependent on β4 integrin, and α6 integrin processing.

@article{Aksoy2014HPV16IO,
  title={HPV16 infection of HaCaTs is dependent on β4 integrin, and α6 integrin processing.},
  author={Pınar Aksoy and Cynthia Y Abban and Elizabeth Kiyashka and Weitao Qiang and Patricio I. Meneses},
  journal={Virology},
  year={2014},
  volume={449},
  pages={45-52}
}
Our understanding of human papillomavirus (HPV) is still evolving. To further study the field, our laboratory has focused on determining the role of integrins in the initial steps of viral endocytosis into HaCaT cells. Our and others' previous findings have shown that α6 is necessary for infection. Here we show that α3 and β1 were dispensable, and we identified integrin α6β4 complex as necessary for infection in HaCaTs. β4 knock down resulted in a significant decrease in HPV16 PsV infection and… CONTINUE READING

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