HPV16 E6 augments Wnt signaling in an E6AP-dependent manner.

  title={HPV16 E6 augments Wnt signaling in an E6AP-dependent manner.},
  author={Hava Lichtig and Daniella Avital Gilboa and Anna Jackman and Pinhas Gonen and Yaara Levav-Cohen and Ygal Haupt and Levana Sherman},
  volume={396 1},
In this study we investigated the effect of HPV16 E6 on the Wnt/beta-catenin oncogenic signaling pathway. Luciferase reporter assays indicated that ectopically expressed E6 significantly augmented the Wnt/beta-catenin/TCF-dependent signaling response in a dose-dependent manner. This activity was independent of the ability of E6 to target p53 for degradation or bind to the PDZ-containing E6 targets. Epistasis experiments suggested that the stimulatory effect is independent of GSK3beta or APC… CONTINUE READING


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