HPV16 E6 and E7 proteins induce a chronic oxidative stress response via NOX2 that causes genomic instability and increased susceptibility to DNA damage in head and neck cancer cells.

@article{Marullo2015HPV16EA,
  title={HPV16 E6 and E7 proteins induce a chronic oxidative stress response via NOX2 that causes genomic instability and increased susceptibility to DNA damage in head and neck cancer cells.},
  author={Rossella Marullo and Erica F Werner and Hongzheng Zhang and Georgia Zhuo Chen and Dong M Shin and Paul W Doetsch},
  journal={Carcinogenesis},
  year={2015},
  volume={36 11},
  pages={
          1397-406
        }
}
Human papillomavirus (HPV) is the causative agent of a subgroup of head and neck cancer characterized by an intrinsic radiosensitivity. HPV initiates cellular transformation through the activity of E6 and E7 proteins. E6 and E7 expression is necessary but not sufficient to transform the host cell, as genomic instability is required to acquire the malignant phenotype in HPV-initiated cells. This study reveals a key role played by oxidative stress in promoting genomic instability and… CONTINUE READING
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