HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

  title={HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.},
  author={Pamela Hawley-Nelson and Karen Heather Vousden and Nancy L. Hubbert and Douglas R Lowy and John T. Schiller},
  journal={The EMBO journal},
  volume={8 12},
The human papillomavirus types (HPVs) most often associated with cancer of the cervix, such as HPV16, have been reported previously to immortalize normal human foreskin keratinocytes in vitro, while the types that are primarily associated with benign cervical lesions failed to do so. In this study we have determined the HPV16 genes that are responsible for the immortalizing activity of the viral genome. Transfection with a plasmid in which E6 and E7 were the only intact open reading frames… CONTINUE READING
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