HPV16 E6 Controls the Gap Junction Protein Cx43 in Cervical Tumour Cells.

@article{Sun2015HPV16EC,
  title={HPV16 E6 Controls the Gap Junction Protein Cx43 in Cervical Tumour Cells.},
  author={Peng Sun and Li Dong and Alasdair Iain Macdonald and Shahrzad Akbari and Michael Kehinde Edward and Malcolm B. Hodgins and Scott Johnstone and Sheila V Graham},
  journal={Viruses},
  year={2015},
  volume={7 10},
  pages={5243-56}
}
Human papillomavirus type 16 (HPV16) causes a range of cancers including cervical and head and neck cancers. HPV E6 oncoprotein binds the cell polarity regulator hDlg (human homologue of Drosophila Discs Large). Previously we showed in vitro, and now in vivo, that hDlg also binds Connexin 43 (Cx43), a major component of gap junctions that mediate intercellular transfer of small molecules. In HPV16-positive non-tumour cervical epithelial cells (W12G) Cx43 localised to the plasma membrane, while… CONTINUE READING
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